Effects of ondansetron on
short-term memory retrieval in mice

by
Roychoudhury M, Kulkarni SK.
Pharmacology Division,
Panjab University,
Chandigarh, India.
Methods Find Exp Clin Pharmacol 1997 Jan-Feb;19(1):43-6


ABSTRACT

Behavioral studies have shown cognitive improvements in various animal models of learning and memory using 5-HT3 receptor antagonists. The present study investigated the cognitive role of ondansetron, a selective 5-HT3 antagonist, in naive and scopolamine-treated mice. Ondansetron attenuated the performance deficits induced by scopolamine (0.3 mg/kg) with both doses employed, although 1.0 mg/kg ondansetron was more effective in ameliorating the deficits as compared to 0.1 mg/kg. However, none of the ondansetron doses (0.01, 0.1 and 1 mg/kg) influenced the performance of naive mice in the passive avoidance step-down paradigm. These results suggest that the 5-HT receptor system, particularly the 5-HT3 receptor, may play a modulating role in learning and memory phenomena in animals.

5-HT3
Exercise
Arecoline
Idebenone
Vinpocetine
Vasopressin
Desmopressin
Meclofenoxate
New brain cells
Centrophenoxine
The memory switch?
Dumb-drug euphoria
Growing new brain cells
Ondansetron versus tropisetron



Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family