Genetic approaches to memory storage
by
Mayford M, Kandel ER.
University of California, San Diego,
Department of Neurosciences,
La Jolla, CA 92093-0691, USA.
mmayford@ucsd.edu
Trends Genet 1999 Nov;15(11):463-70

ABSTRACT

The ability to remember is perhaps the most significant and distinctive feature of our mental life. We are who we are largely because of what we have learned and what we remember. In turn, impairments in learning and memory can lead to disorders that range from the moderately inconvenient benign senescent forgetfulness associated with normal aging to the devastating memory losses associated with Alzheimer disease. Of the various, higher-cognitive abilities that human beings possess, such as reasoning and language, memory is the only one that can be studied effectively in simple experimental organisms that are accessible to genetic manipulation, such as snails, flies and mice. In these organisms, the effectiveness of genetic approaches in the study of memory has improved significantly in the past five years. Below we review these advances.

CREB
New brain cells
Fruit-fly memories
CREBs and memory
The memory switch?
Dumb-drug euphoria
Growing new brain cells
Photographic memory in flies
CREB and long-term memory
Memory promoters and suppressors
The CREB pathway and memory enhancers

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