Peripheral delivery of a ROCK inhibitor improves learning and working memory
by
Huentelman MJ, Stephan DA, Talboom J, Corneveaux JJ, Reiman DM,
Gerber JD, Barnes CA, Alexander GE, Reiman EM, Bimonte-Nelson HA.
Neurogenomics Division.
Behav Neurosci. 2009 Feb;123(1):218-23.
ABSTRACTPreviously, utilizing a series of genome-wide association, brain imaging, and gene expression studies we implicated the KIBRA gene and the RhoA/ROCK pathway in hippocampal-mediated human memory. Here we show that peripheral administration of the ROCK inhibitor hydroxyfasudil improves spatial learning and working memory in the rodent model. This study supports the action of ROCK on learning and memory, suggests the potential value of ROCK inhibition for the promotion of cognition in humans, and highlights the powerful potential of unbiased genome-wide association studies to inform potential novel uses for existing pharmaceuticals.New brain cells
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