Design and study of some novel ibuprofen derivatives with potential nootropic and neuroprotective properties
Siskou IC, Rekka EA, Kourounakis AP, Chrysselis MC, Tsiakitzis K, Kourounakis PN.
Department of Pharmaceutical Chemistry, School of Pharmacy,
Aristotelian University of Thessaloniki,
Thessaloniki 54124, Greece.
Bioorg Med Chem. 2007 Jan 15;15(2):951-61.

ABSTRACT

Six novel ibuprofen derivatives and related structures, incorporating a proline moiety and designed for neurodegenerative disorders, are studied. They possess anti-inflammatory properties and three of them inhibited lipoxygenase. One compound was found to inhibit cyclooxygenase (COX)-2 production in spleenocytes from arthritic rats. The HS-containing compounds are potent antioxidants and one of them protected against glutathione loss after cerebral ischemia/reperfusion. They demonstrated lipid-lowering ability and seem to acquire low gastrointestinal toxicity. Acetylcholinesterase inhibitory activity, found in two of these compounds, may be an asset to their actions.

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