Effect of rubiscolin, a delta opioid peptide
derived from Rubisco, on memory consolidation
by
Yang S, Kawamura Y, Yoshikawa M.
Division of Food Bioscience and Biotechnology,
Graduate School of Agriculture,
Kyoto University, Uji,
611-0011, Kyoto, Japan.
Peptides. 2003 Feb;24(2):325-8

ABSTRACT

Rubiscolin-6 (YPLDLF) is a delta selective opioid peptide isolated from the enzymatic digests of ribulose bisphosphate carboxylase/oxygenase (Rubisco) from spinach leaves. In a step-through type passive avoidance test in ddY mice, rubiscolin-6 enhanced memory consolidation at doses of 3nmol/mouse after intracerebroventricular administration, and at 100mg/kg after oral administration. These doses are smaller than the optimal doses for an analgesic effect. The memory enhancing effect of rubiscolin-6 was blocked by pretreatment with the delta antagonist naltrindole, suggesting the involvement of the delta opioid receptor.

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